Pa 30, yokohama rabara Cola {{1} adalengeza kuti zapanga bwino rabachi) rubbers {{3}
Mu 2013, Yokohama rabara a rabara ndi Ryan mankhwala adayamba phunziroli, kugwiritsa ntchito njira yopangira makompyuta kuti apeze njira yatsopano ya isoprene pazaka ziwiri {{}
Yokohama ananena kuti magulu atatuwo akhazikitsanso ukadaulo watsopanowu, kutengera enzyme yopangidwa ndi iyo, yomwe imapangidwa ndi shuprais (nthawi zambiri) mphira {{1}
Yokohama adatola kuti isoprene amaganiza kuti mwachilengedwe amapangidwa mwachilengedwe ndi pentanoic acid
Kampaniyo idanenanso kuti enzyme yogwira kwambiri ili ndi mphamvu yodabwitsa ya isoprene yomwe siyingatheke ndi ma enzymes achilengedwe .